慢性丙型肝炎病毒感染患者的支气管肺泡灌洗 fluid 检查结果 。（注：这里“fluid”可能是“液体”之意，结合医学语境，推测完整表述可能是“支气管肺泡灌洗液体检查结果” ，但仅依据提供英文准确翻译就是上述内容 ）
Bronchoalveolar lavage fluid findings in patients with chronic hepatitis C virus infection.
作者信息
Kubo K, Yamaguchi S, Fujimoto K, Hanaoka M, Hayasaka M, Honda T, Sodeyama T, Kiyosawa K
机构信息
First Department of Internal Medicine, Shinshu University, School of Medicine, Matsumoto, Japan.
出版信息
Thorax. 1996 Mar;51(3):312-4. doi: 10.1136/thx.51.3.312.
BACKGROUND
Hepatitis C virus (HCV) infection has recently been incriminated as an aetiological agent in idiopathic pulmonary fibrosis. This study was performed to determine the cellularity and lymphocyte phenotypes of bronchoalveolar lavage (BAL) fluid in patients with chronic hepatitis C.
METHODS
BAL fluid and lavage lymphocyte subsets from 13 patients (10 men) with active chronic hepatitis C, diagnosed by sustained elevated serum glutamic pyruvic transaminase and typical histological findings in the liver, were analysed. Lavage findings in these patients were compared with those from 13 healthy volunteers (eight men) as controls.
RESULTS
There was no difference in total cell counts in lavage fluid between the two groups. Lavage lymphocyte and eosinophil numbers were increased in patients with chronic hepatitis C. Surface marker analysis of the lymphocyte populations showed increases in CD2, CD3, CD4, and HLA-DR. CD4/CD8 ratios were not different.
CONCLUSIONS
The numbers of lymphocytes and eosinophils in BAL fluid are increased in patients with chronic hepatitis C. These findings suggest that HCV infection may trigger alveolitis.
背景
最近丙型肝炎病毒（HCV）感染被认为是特发性肺纤维化的病因之一。本研究旨在确定慢性丙型肝炎患者支气管肺泡灌洗（BAL）液中的细胞成分和淋巴细胞表型。
方法
分析了13例（10例男性）活动性慢性丙型肝炎患者的BAL液和灌洗淋巴细胞亚群，这些患者通过持续升高的血清谷丙转氨酶和典型的肝脏组织学表现确诊。将这些患者的灌洗结果与13名健康志愿者（8名男性）作为对照的结果进行比较。
结果
两组灌洗液中的总细胞计数没有差异。慢性丙型肝炎患者的灌洗淋巴细胞和嗜酸性粒细胞数量增加。淋巴细胞群体的表面标志物分析显示CD2、CD3、CD4和HLA-DR增加。CD4/CD8比值没有差异。
结论
慢性丙型肝炎患者BAL液中的淋巴细胞和嗜酸性粒细胞数量增加。这些发现表明HCV感染可能引发肺泡炎。
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