HIV 感染与女性弥散量损害有关。
HIV infection is associated with diffusing capacity impairment in women.
机构信息
*Department of Medicine, University of Pittsburgh, Pittsburgh, PA; †Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA; ‡Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA; Departments of §Medicine; ‖Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, CA; and ¶Department of Immunology, University of Pittsburgh, Pittsburgh, PA.
出版信息
J Acquir Immune Defic Syndr. 2013 Nov 1;64(3):284-8. doi: 10.1097/QAI.0b013e3182a9213a.
Respiratory dysfunction is common with HIV infection, but few studies have directly assessed whether HIV remains an independent risk factor for pulmonary function abnormalities in the antiretroviral therapy era. Additionally, few studies have focused on pulmonary outcomes in HIV+ women. We tested associations between risk factors for respiratory dysfunction and pulmonary outcomes in 63 HIV+ and 36 HIV-uninfected women enrolled in the Women's Interagency HIV Study. Diffusing capacity (DL(CO)) was significantly lower in HIV+ women (65.5% predicted vs. 72.7% predicted, P = 0.01), and self-reported dyspnea in HIV+ participants was associated with both DL(CO) impairment and airflow obstruction. Providers should be aware that DL(CO) impairment is common in HIV infection, and that either DL(CO) impairment or airflow obstruction may cause respiratory symptoms in this population.
呼吸功能障碍在 HIV 感染中很常见，但很少有研究直接评估在抗逆转录病毒治疗时代，HIV 是否仍然是肺功能异常的独立危险因素。此外，很少有研究关注 HIV 阳性女性的肺部结局。我们在 Women's Interagency HIV Study 中招募了 63 名 HIV 阳性和 36 名 HIV 阴性女性，检测了呼吸功能障碍的危险因素与肺部结局之间的关联。HIV 阳性女性的弥散量（DL(CO)）明显较低（预测值 65.5%对预测值 72.7%，P=0.01），HIV 阳性参与者自述呼吸困难与 DL(CO)损害和气流阻塞均相关。医务人员应注意到，DL(CO)损害在 HIV 感染中很常见，在该人群中，DL(CO)损害或气流阻塞都可能导致呼吸症状。
Zotero 插件