Reyes J G
Instituto de Química, Universidad Católica de Valparaíso, Chile.
Am J Physiol. 1996 Feb;270(2 Pt 1):C401-10. doi: 10.1152/ajpcell.1996.270.2.C401.
The importance of zinc in cell physiology is related mainly to its intracellular involvement in enzyme catalysis, protein structure, protein-protein interactions, and protein-oligonucleotide interactions. The mechanisms by which Zn2+ enters mammalian cells have been studied in a variety of cell systems. A review of this literature indicates that, in all cells, Zn2+ interacts with extracellular binding sites, which are likely to include binding sites involved in the subsequent translocation of this ion to the cell interior. Inside the cell, Zn2+ binds to cytosolic and organelle binding sites or is taken up by intracellular organelles. Despite these general conclusions, the mechanisms of the different transport and binding steps are, for most cell types, only partially solved. This review critically discusses the literature on mammalian Zn2+ transport and outlines some critical points for future research of the mechanisms of transport of this ion.
锌在细胞生理学中的重要性主要与其在细胞内参与酶催化、蛋白质结构、蛋白质 - 蛋白质相互作用以及蛋白质 - 寡核苷酸相互作用有关。锌离子（Zn2+）进入哺乳动物细胞的机制已在多种细胞系统中得到研究。对该文献的综述表明，在所有细胞中，Zn2+与细胞外结合位点相互作用，这些位点可能包括参与该离子随后转运至细胞内部的结合位点。在细胞内部，Zn2+与胞质和细胞器结合位点结合或被细胞内细胞器摄取。尽管有这些一般性结论，但对于大多数细胞类型而言，不同运输和结合步骤的机制仅得到部分解决。本综述批判性地讨论了关于哺乳动物Zn +运输的文献，并概述了该离子运输机制未来研究的一些关键点。
