Levine J, Aviram A, Holan A, Ring A, Barak Y, Belmaker R H
Abarbanel Mental Health Center, Bat Yam, Israel.
J Neural Transm (Vienna). 1997;104(2-3):307-10. doi: 10.1007/BF01273191.
Recent studies suggest that serotonin reuptake inhibitors are helpful in at least some symptoms of autism. Inositol is a precursor of the second messenger for some serotonin receptors, and has been reported effective in depression, panic disorder and obsessive-compulsive disorder. However a controlled double-blind crossover trial of inositol 200 mg/kg per day showed no benefit on 9 children with autism. Since biochemical studies could evaluate inositol in children already receiving serotonin reuptake inhibitors.
最近的研究表明，血清素再摄取抑制剂对自闭症的至少某些症状有帮助。肌醇是某些血清素受体第二信使的前体，据报道对抑郁症、恐慌症和强迫症有效。然而，一项每天200毫克/千克肌醇的对照双盲交叉试验显示，对9名自闭症儿童没有益处。因为生化研究可以评估已经在服用血清素再摄取抑制剂的儿童体内的肌醇。
