Sonobe H, Ohtsuki Y, Mizobuchi H, Toda M, Shimizu K
Department of Pathology, Kochi Medical School, Japan.
Cancer Genet Cytogenet. 1996 Aug;90(1):54-6. doi: 10.1016/0165-4608(96)00070-2.
A t(X;10)(q22;q23.2) translocation was detected as the only chromosomal aberration in primary short-term cultured cells from an angiomyoma of a 58-year-old woman; 6p, 13q, and 21q rearrangements have been previously demonstrated by others in two cases of angiomyoma. This type of translocation has not been reported in other benign tumors including leiomyomas and angiomyomas, although it has been detected in an ependymoma. This is thought to be a third case of angiomyoma showing karyotypic abnormalities.
在一名58岁女性血管平滑肌瘤的原代短期培养细胞中，检测到t(X;10)(q22;q23.2)易位，这是唯一的染色体畸变；此前在另外两例血管平滑肌瘤中，其他人已证实存在6p、13q和21q重排。这种类型的易位在包括平滑肌瘤和血管平滑肌瘤在内的其他良性肿瘤中尚未见报道，尽管在一例室管膜瘤中检测到过。这被认为是第三例显示核型异常的血管平滑肌瘤。
