An endometrial polyp with a rearrangement of HMGI-C underlying a complex cytogenetic rearrangement involving chromosomes 2 and 12.

作者信息

Bol S, Wanschura S, Thode B, Deichert U, Van de Ven W J, Bartnitzke S, Bullerdiek J

机构信息

Center of Human Genetics and Genetic Counselling, University of Bremen, Germany.

出版信息

Cancer Genet Cytogenet. 1996 Aug;90(1):88-90. doi: 10.1016/0165-4608(96)00062-3.

Cytogenetic studies of an endometrial polyp of an 82-year-old patient revealed a karyotype 46,XX,der(2)inv(2)(p25q21)ins(2;12)(p25;q13q14)t(2;12)(q21; q15),der(12)del(12)(q13q14)del(12)(q15). By fluorescence in situ hybridization (FISH) we found the chromosome 12 translocation breakpoint to be mapping within the third intron of the HMGI-C gene also harboring the breakpoints of translocations involving 12q15 seen in uterine leiomyomas, lipomas, pleomorphic adenomas, and pulmonary chondroid hamartomas.