Serraino D, Franceschi S, Greco D, Carbone A, Monfardini S, Tirelli U
Epidemiology Unit, Aviano Cancer Centre, Italy.
J Acquir Immune Defic Syndr (1988). 1994 Nov;7(11):1202-7.
To evaluate the completeness and accuracy in the reporting of AIDS-associated Kaposi's sarcoma (KS) and non-Hodgkin's lymphomas (NHL) in Italy, a linkage study of the notifications to the Italian AIDS Registry (RAIDS--the national compulsory AIDS surveillance system) and the clinical and pathological records of the Italian Cooperative Group on AIDS-related tumors (GICAT--a nationwide voluntary reporting system for HIV-infected individuals who develop cancer) was carried out. A total of 288 cases of KS and 258 cases of NHL fulfilling the AIDS definition criteria, histologically diagnosed by the GICAT centers between January 1987 and March 1992, were matched with the 16,860 AIDS cases reported to the RAIDS up to March 1993. The linkage procedure, based on name, gender, and date of birth, identified 276 cases of KS (96%) and 241 cases of NHL (93%) present in both files ("linked" cases). The diagnosis of KS did not appear among the clinical manifestations of AIDS in the RAIDS file in 67 out of the 276 linked KS (24%), either with coincident dates of KS diagnosis and of case notification (19 cases) or when the KS diagnosis followed by > or = 2 months the case notification to RAIDS (48 cases). Of the 241 linked NHL, 84 (33%) had no such neoplastic complications of AIDS listed in the RAIDS file, 23 with coincident dates of NHL diagnosis and of case notification and 61 with the NHL diagnosis made > or = 2 months after the notification. A noteworthy discrepancy in the classification of the three histologic subtypes of NHL emerged between the GICAT and the RAIDS. The degree of underreporting of AIDS-associated cancers that emerged from the present study suggests that augmentation with other sources of oncological information is important to better estimate the burden of AIDS-related tumors and to study the interaction between HIV infection and cancer.
为评估意大利艾滋病相关卡波西肉瘤（KS）和非霍奇金淋巴瘤（NHL）报告的完整性和准确性，开展了一项关联研究，将意大利艾滋病登记处（RAIDS，国家强制性艾滋病监测系统）的报告与意大利艾滋病相关肿瘤合作组（GICAT，针对感染HIV并患癌症个体的全国性自愿报告系统）的临床和病理记录进行关联。1987年1月至1992年3月期间，GICAT中心经组织学诊断的288例符合艾滋病定义标准的KS病例和258例NHL病例，与截至1993年3月向RAIDS报告的16860例艾滋病病例进行匹配。基于姓名、性别和出生日期的关联程序，在两个档案中均识别出276例KS病例（96%）和241例NHL病例（93%）（“关联”病例）。在276例关联的KS病例中，有67例（24%）在RAIDS档案的艾滋病临床表现中未出现KS诊断，其中KS诊断与病例报告日期一致的有19例，或者KS诊断在向RAIDS报告病例后≥2个月的有48例。在241例关联的NHL病例中，有84例（33%）在RAIDS档案中未列出此类艾滋病相关肿瘤并发症，其中NHL诊断与病例报告日期一致的有23例，NHL诊断在报告后≥2个月的有61例。GICAT和RAIDS在NHL三种组织学亚型的分类上存在显著差异。本研究中出现的艾滋病相关癌症报告不足程度表明，增加其他肿瘤信息来源对于更好地估计艾滋病相关肿瘤负担以及研究HIV感染与癌症之间的相互作用很重要。
