Caplan R, Guthrie D, Komo S
Department of Psychiatry, University of California at Los Angeles, USA.
Biol Psychiatry. 1996 Jun 15;39(12):1032-8. doi: 10.1016/0006-3223(95)00315-0.
Spontaneous blink rate, a noninvasive measure of dopamine function, was coded in 28 children with attention-deficit-hyperactivity disorder (ADHD) and in 47 normal children during a listening, a conversation, and a verbal recall task. Unlike the normal children, the children with ADHD did not increase their blink rates significantly across these three tasks. The ADHD subjects were were not on stimulants had significantly lower blink rates than the normal children during verbal recall. The ADHD subjects on stimulants, however, had significantly higher blink rates than the normal subjects during the listening task. These preliminary findings are discussed in light of their potential implications for theories on neurotransmitter dysfunction and arousal in ADHD.
作为一种评估多巴胺功能的非侵入性指标，对28名患有注意力缺陷多动障碍（ADHD）的儿童以及47名正常儿童在听力、对话和言语回忆任务期间的自发眨眼率进行了记录。与正常儿童不同，患有ADHD的儿童在这三项任务中眨眼率并未显著增加。未服用兴奋剂的ADHD受试者在言语回忆期间的眨眼率显著低于正常儿童。然而，服用兴奋剂的ADHD受试者在听力任务期间的眨眼率显著高于正常受试者。本文根据这些初步发现对ADHD中神经递质功能障碍和唤醒理论的潜在影响进行了讨论。
