Gleich L L, Biddinger P W, Pavelic Z P, Gluckman J L
Department of Otolaryngology--Head and Neck Surgery, University of Cincinnati Medical Center 45267-0528, USA.
Head Neck. 1996 Jul-Aug;18(4):343-6. doi: 10.1002/(SICI)1097-0347(199607/08)18:4<343::AID-HED5>3.0.CO;2-Y.
Angiogenesis is necessary for tumor growth and metastasis. In breast and other cancers angiogenesis has been shown to correlate with tumor size, metastatic potential, and prognosis. Some studies of head and neck cancer have shown a similar correlation, although results are inconclusive. This study was performed to determine whether tumor angiogenesis can be used as a prognostic indicator for early oral cancers.
CD-31 immunostaining, the technique of choice for determining microvessel density, was utilized to investigate T1 squamous cell carcinomas of the ventral tongue and floor of the mouth.
Adequate staining was achieved in 19 tumors. Seven tumors were deemed aggressive due to either the development of metastases or recurrence. The mean microvessel density in the aggressive patients was 43.1/hpf (range 15--79) and in the nonaggressive patients was 38.6/hpf (range 17--78). Statistical analysis failed to reveal any correlation between tumor aggressiveness and tumor angiogenesis in these early tumors.
Tumor angiogenesis failed to predict tumor aggressiveness in T1 oral cavity carcinoma; however, low levels of neoangiogenesis were seen in all cases. For this reason this technique may prove more valuable in more advanced cancers.
血管生成是肿瘤生长和转移所必需的。在乳腺癌和其他癌症中，血管生成已被证明与肿瘤大小、转移潜能和预后相关。一些头颈癌研究也显示了类似的相关性，尽管结果尚无定论。本研究旨在确定肿瘤血管生成是否可作为早期口腔癌的预后指标。
采用CD-31免疫染色（确定微血管密度的首选技术）来研究舌腹和口底的T1期鳞状细胞癌。
19个肿瘤实现了充分染色。7个肿瘤因发生转移或复发而被视为侵袭性肿瘤。侵袭性患者的平均微血管密度为43.1/高倍视野（范围15 - 79），非侵袭性患者为38.6/高倍视野（范围17 - 78）。统计分析未能揭示这些早期肿瘤的肿瘤侵袭性与肿瘤血管生成之间的任何相关性。
肿瘤血管生成未能预测T1期口腔癌的肿瘤侵袭性；然而，所有病例均可见低水平的新生血管生成。因此，该技术可能在更晚期癌症中更具价值。
