Takeuchi H, Matsuo T, Tokuyama K, Suzuki M
Research Laboratory, Nisshin Oil Mills, Ltd., Yokosuka, Japan.
J Nutr Sci Vitaminol (Tokyo). 1996 Apr;42(2):161-6. doi: 10.3177/jnsv.42.161.
Effect of dietary fat type on beta-oxidation of brown adipose tissue and Na+ channel density of brain nerve membrane was studied in rats. Rats were fed an experimental diet containing lard, high oleic safflower oil, safflower oil or linseed oil for 12 weeks. The activities of carnitine palmitoyltransferase and cytochrome oxidase in brown adipose tissue were significantly lower in rats fed the lard diet than in those fed the high-oleic safflower oil diet, safflower oil diet or linseed oil diet. However, the peroxisomal beta-oxidation activity in brown adipose tissue was significantly higher in rats fed the lard diet than in those fed the other diet. The Na+ channel density in brain nerve membrane was not significantly different among the diet groups. These results suggest that intake of the lard diet rich in saturated fatty acids, compared with the vegetable oil diets rich in unsaturated fatty acids decrease mitochondrial beta-oxidation in brown adipose tissue, and that the dietary fat type has a differential effect on mitochondrial and peroxisomal beta-oxidation in brown adipose tissue.
在大鼠中研究了膳食脂肪类型对棕色脂肪组织β-氧化和脑神经膜钠通道密度的影响。给大鼠喂食含有猪油、高油酸红花油、红花油或亚麻籽油的实验性饮食12周。喂食猪油饮食的大鼠棕色脂肪组织中肉碱棕榈酰转移酶和细胞色素氧化酶的活性显著低于喂食高油酸红花油饮食、红花油饮食或亚麻籽油饮食的大鼠。然而，喂食猪油饮食的大鼠棕色脂肪组织中的过氧化物酶体β-氧化活性显著高于喂食其他饮食的大鼠。饮食组之间脑神经膜中的钠通道密度没有显著差异。这些结果表明，与富含不饱和脂肪酸的植物油饮食相比，摄入富含饱和脂肪酸的猪油饮食会降低棕色脂肪组织中的线粒体β-氧化，并且膳食脂肪类型对棕色脂肪组织中的线粒体和过氧化物酶体β-氧化有不同的影响。
