Lepage P, Msellati P, Hitimana D G, Bazubagira A, Van Goethem C, Simonon A, Karita E, Dequae-Merchadou L, Van de Perre P, Dabis F
Department of Pediatrics, Centre Hospitalier de Kigali, Rwanda.
Pediatr Infect Dis J. 1996 Jun;15(6):479-85. doi: 10.1097/00006454-199606000-00003.
To compare the anthropometric characteristics of children with and without HIV-1 infection.
In a prospective cohort study of 218 children born to HIV-1 seropositive mothers and 218 children born to HIV-1 seronegative mothers in Kigali, Rwanda, 3 groups were compared: infected children (n = 46); uninfected children born to seropositive mothers (n = 140); and uninfected children born to seronegative mothers (n = 207). Weight, height and head circumference were measured at birth, every 3 months during the first year of life and every 6 months thereafter. The weight-for-age, height-for-age, weight-for-height and head circumference-for-age mean z scores were calculated.
The weight-for-age, height-for-age and head circumference-for-age mean z scores were lower among HIV-infected children than among uninfected ones at each time period. The reduction in the weight-for-age mean z score was the greatest between 12 and 36 months. The reduction in the height-for-age mean z score of HIV-infected children was persistently below 2 SD after 9 months of age. On the other hand the weight-for-height mean z score was not consistently lower in HIV-infected children when compared with uninfected ones. The anthropometric characteristics of uninfected children born to seropositive mothers were similar to those of children born to seronegative mothers.
In this study HIV-infected children were more frequently stunted (low height-for-age) than uninfected ones. Wasting (low weight-for-height) was not common among HIV-infected children.
比较感染和未感染HIV-1的儿童的人体测量学特征。
在卢旺达基加利进行的一项前瞻性队列研究中，对218名HIV-1血清阳性母亲所生儿童和218名HIV-1血清阴性母亲所生儿童进行了比较，分为3组：感染儿童（n = 46）；血清阳性母亲所生未感染儿童（n = 140）；以及血清阴性母亲所生未感染儿童（n = 207）。在出生时、生命的第一年每3个月以及此后每6个月测量体重、身高和头围。计算年龄别体重、年龄别身高、身高别体重和年龄别头围的平均z评分。
在每个时间段，HIV感染儿童的年龄别体重、年龄别身高和年龄别头围平均z评分均低于未感染儿童。年龄别体重平均z评分在12至36个月之间下降幅度最大。HIV感染儿童的年龄别身高平均z评分在9个月龄后持续低于2个标准差。另一方面，与未感染儿童相比，HIV感染儿童的身高别体重平均z评分并非一直较低。血清阳性母亲所生未感染儿童的人体测量学特征与血清阴性母亲所生儿童相似。
在本研究中，HIV感染儿童比未感染儿童更频繁地出现发育迟缓（年龄别身高低）。消瘦（身高别体重低）在HIV感染儿童中并不常见。
