Chattopadhyay Arpita, Bhattacharyya Subhashis, Dhar Subhashish
Postgraduate Student, Department of Pediatrics, Medical College and Hospital , 88, College Street, Kolkata, India .
Associate Professor, Department of Pediatrics, Medical College and Hospital , 88, College Street, Kolkata, India .
J Clin Diagn Res. 2016 May;10(5):SC14-6. doi: 10.7860/JCDR/2016/16996.7889. Epub 2016 May 1.
To evaluate the nutritional status of HIV seropositive children, aged 2-10 years with age - matched controls and examine the role of nutritional intervention and HRT on their growth indices.
It was a cross-sectional study done at a HIV Clinic of a teaching hospital. Fifty six seropositive children (age 2-10 year) classified as cases, and 60 seronegative age - matched controls were taken. Demographic and anthropometric characteristics were collected via valid instruments. HIV grading and adherence to HRT were assessed by using validated questionnaires.
Of the cases majority (87.5%) were infected by vertical transmission from mother to child, the remaining were infected by blood transfusion out of which 1.78% were haemophiliacs and remaining were thalassaemics. The prevalence of underweight among cases was 64.3%, compared to prevalence of 61% among controls. The prevalence of stunting was 44.6% among cases, while the prevalence of severe stunting was 14.3%. The prevalence of wasting among cases was 30.35%, while 7% cases were severely wasted. Only 23.33% controls were wasted. There was a significant difference in the Height- for-age between cases and controls, in the age of 4 years, 5 years and 6 years (p-value <0.05).
There was a significant difference in the Height- for-age between cases and controls, in the age of 4 years, 5 years and 6 years, indicating the need for proper nutritional intervention and timely HIV antiretroviral therapy to prevent stunting.
评估2至10岁HIV血清阳性儿童与年龄匹配的对照组儿童的营养状况，并研究营养干预和高效抗逆转录病毒治疗（HRT）对其生长指标的作用。
这是一项在一家教学医院的HIV诊所开展的横断面研究。选取了56名血清阳性儿童（年龄2至10岁）作为病例组，以及60名年龄匹配的血清阴性对照组儿童。通过有效的工具收集人口统计学和人体测量学特征。使用经过验证的问卷评估HIV分级和对HRT的依从性。
在病例组中，大多数（87.5%）是通过母婴垂直传播感染的，其余是通过输血感染的，其中1.78%是血友病患者，其余是地中海贫血患者。病例组中体重不足的患病率为64.3%，对照组为61%。病例组中发育迟缓的患病率为44.6%，重度发育迟缓的患病率为14.3%。病例组中消瘦的患病率为30.35%，7%的病例为重度消瘦。对照组中只有23.33%消瘦。病例组和对照组在4岁、5岁和6岁时的年龄别身高存在显著差异（p值<0.05）。
病例组和对照组在4岁、5岁和6岁时的年龄别身高存在显著差异，这表明需要进行适当的营养干预和及时的HIV抗逆转录病毒治疗以预防发育迟缓。
