Irie S, Saito T, Nakamura K, Kanazawa N, Ogino M, Nukazawa T, Ito H, Tamai Y, Kowa H
Department of Neurology, Kitasato University East Hospital, Kanagawa, Japan.
J Neuroimmunol. 1996 Aug;68(1-2):19-26. doi: 10.1016/0165-5728(96)00059-8.
We examined serum anti-cytomegalovirus (CMV) and anti-ganglioside antibodies by ELISA in 51 patients with Guillain-Barré syndrome (GBS), and titers were compared with those from 47 normal and 74 disease controls. Three GBS patients with IgM anti-CMV antibodies had high titers of IgM and IgG anti-GM2 antibodies. The other GBS patients without IgM anti-CMV antibodies, and the normal and disease controls except one of 6 non-GBS patients with acute CMV infections had no anti-GM2 antibodies. The titers of anti-GM2 antibodies decreased on absorption with CMV-infected cells. These findings suggest that anti-GM2 antibodies are associated with acute CMV infections in GBS patients.
我们通过酶联免疫吸附测定法（ELISA）检测了51例吉兰-巴雷综合征（GBS）患者的血清抗巨细胞病毒（CMV）抗体和抗神经节苷脂抗体，并将滴度与47名正常对照者和74名疾病对照者的滴度进行了比较。3例伴有IgM抗CMV抗体的GBS患者具有高滴度的IgM和IgG抗GM2抗体。其他不伴有IgM抗CMV抗体的GBS患者，以及除1例急性CMV感染的非GBS患者外的正常对照者和疾病对照者均无抗GM2抗体。抗GM2抗体的滴度在用CMV感染细胞吸收后降低。这些发现表明，抗GM2抗体与GBS患者的急性CMV感染有关。
