吉兰-巴雷综合征中的巨细胞病毒感染与抗GM2抗体
Cytomegalovirus infections and anti-GM2 antibodies in Guillain-Barré syndrome.
作者信息
Jacobs B C, van Doorn P A, Groeneveld J H, Tio-Gillen A P, van der Meché F G
机构信息
Department of Neurology, University Hospital Dijkzigt and Erasmus University, Rotterdam, The Netherlands.
出版信息
J Neurol Neurosurg Psychiatry. 1997 Jun;62(6):641-3. doi: 10.1136/jnnp.62.6.641.
Abstract
To investigate whether antecedent cytomegalovirus (CMV) infections in patients with Guillain-Barré syndrome are associated with the presence of specific antiganglioside antibodies, acute phase serum samples from 130 patients with Guillain-Barré syndrome and 200 controls were tested. Anti-GM2 IgM antibodies were found more often in patients with Guillain-Barré syndrome with CMV infection (22%) than in patients without the infection (2%) (P = 0.003). CMV infections may elicit anti-GM2 antibodies in susceptible patients, which may contribute to the pathogenesis of Guillain-Barré syndrome associated with CMV.
摘要
为研究吉兰-巴雷综合征患者既往巨细胞病毒（CMV）感染是否与特定抗神经节苷脂抗体的存在相关，检测了130例吉兰-巴雷综合征患者和200例对照的急性期血清样本。在伴有CMV感染的吉兰-巴雷综合征患者中，抗GM2 IgM抗体的检出率（22%）高于未感染患者（2%）（P = 0.003）。CMV感染可能在易感患者中引发抗GM2抗体，这可能与CMV相关的吉兰-巴雷综合征的发病机制有关。
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