Kadono T, Kikuchi K, Kubo M, Fujimoto M, Tamaki K
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
J Am Acad Dermatol. 1996 Sep;35(3 Pt 1):392-7. doi: 10.1016/s0190-9622(96)90603-9.
Basic fibroblast growth factor (bFGF), a cytoplasmic polypeptide growth regulator that induces endothelial cell and fibroblast proliferation, is produced by endothelial cells and skeletal muscle.
We hypothesized that this factor is involved in fibrotic changes in muscle and skin in collagen diseases.
The serum level of bFGF was measured in 74 patients with systemic sclerosis, 12 with systemic lupus erythematosus, 33 with dermatomyositis, 13 with Raynaud's disease, and 20 control subjects.
bFGF was undetectable in the serum of normal persons, but detectable levels were found in 31 of 74 patients with systemic sclerosis and 7 of 33 patients with dermatomyositis. Elevated serum bFGF level was correlated with an elevated plasma endothelin level and anticentromere antibody in patients with systemic sclerosis. An elevated serum bFGF level correlated with lung fibrosis and an elevated creatine kinase level in the patients with dermatomyositis.
Measurement of the serum bFGF level may be useful to detect vascular damage in patients with systemic sclerosis and muscule fibrosis in patients with dermatomyositis.
碱性成纤维细胞生长因子（bFGF）是一种诱导内皮细胞和成纤维细胞增殖的细胞质多肽生长调节因子，由内皮细胞和骨骼肌产生。
我们推测该因子参与胶原病中肌肉和皮肤的纤维化改变。
测定了74例系统性硬化症患者、12例系统性红斑狼疮患者、33例皮肌炎患者、13例雷诺病患者及20例对照者血清中bFGF水平。
正常人血清中未检测到bFGF，但74例系统性硬化症患者中有31例、33例皮肌炎患者中有7例检测到可测水平。系统性硬化症患者血清bFGF水平升高与血浆内皮素水平升高及抗着丝点抗体相关。皮肌炎患者血清bFGF水平升高与肺纤维化及肌酸激酶水平升高相关。
测定血清bFGF水平可能有助于检测系统性硬化症患者的血管损伤及皮肌炎患者的肌肉纤维化。
