乙酸1'-乙酰氧基胡椒酚酯，一种超氧阴离子生成抑制剂，能有效抑制12-O-十四烷酰佛波醇-13-乙酸酯对ICR小鼠皮肤的肿瘤促进作用。
1'-Acetoxychavicol acetate, a superoxide anion generation inhibitor, potently inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in ICR mouse skin.
作者信息
Murakami A, Ohura S, Nakamura Y, Koshimizu K, Ohigashi H
机构信息
Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki University, Wakayama, Japan.
出版信息
Oncology. 1996 Sep-Oct;53(5):386-91. doi: 10.1159/000227593.
The anti-tumor-promoting activity of 1'-acetoxychavicol acetate (ACA) was examined in a two-stage carcinogenesis experiment in ICR mouse skin using 7,12-dimethylbenz[a]anthracene (0.19 mumol) and 12-O-tetradecanoylphorbol-13-acetate (TPA; 1.6 nmol). Topical application of ACA (160 nmol) markedly reduced the average number of tumors per mouse and the ratio of tumor-bearing mice: inhibition ratios 90% (p < 0.001) and 42% (p < 0.005), respectively. ACA even at a dose equimolar to TPA (1.6 nmol) significantly reduced the average number of tumors per mouse: inhibitory ratio 44% (p < 0.05). ACA potently inhibited TPA-induced superoxide (O2-) generation in differentiated HL-60 cells (IC50 = 4.3 microM) and suppressed the lipid hydroperoxide formation by 42% (p < 0.001) in the ethyl linoleate autoxidation test.
使用7,12 - 二甲基苯并[a]蒽（0.19 μmol）和12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA；1.6 nmol），在ICR小鼠皮肤的两阶段致癌实验中检测了乙酸1'-乙酰氧基查维醇（ACA）的抗肿瘤促进活性。局部应用ACA（160 nmol）显著降低了每只小鼠的平均肿瘤数量和荷瘤小鼠的比例：抑制率分别为90%（p < 0.001）和42%（p < 0.005）。即使在与TPA等摩尔的剂量（1.6 nmol）下，ACA也显著降低了每只小鼠的平均肿瘤数量：抑制率为44%（p < 0.05）。ACA在分化的HL - 60细胞中有效抑制TPA诱导的超氧化物（O2-）生成（IC50 = 4.3 μM），并且在亚油酸乙酯自氧化试验中抑制脂质过氧化氢形成42%（p < 0.001）。
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