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1
A reciprocal cell-cell interaction mediated by NT-3 and neuregulins controls the early survival and development of sympathetic neuroblasts.由NT-3和神经调节蛋白介导的双向细胞间相互作用控制着交感神经母细胞的早期存活和发育。
Neuron. 1996 Mar;16(3):515-27. doi: 10.1016/s0896-6273(00)80071-9.
2
NT-3 stimulates sympathetic neuroblast proliferation by promoting precursor survival.
Neuron. 1993 Dec;11(6):1101-11. doi: 10.1016/0896-6273(93)90223-e.
3
Subpopulations of rat B2(+) neuroblasts exhibit differential neurotrophin responsiveness during sympathetic development.
Dev Biol. 2000 Feb 15;218(2):367-77. doi: 10.1006/dbio.1999.9591.
4
Neurotrophins regulate sequential changes in neurotrophin receptor expression by sympathetic neuroblasts.神经营养因子调节交感神经母细胞神经营养因子受体表达的顺序性变化。
Neuron. 1994 Dec;13(6):1359-72. doi: 10.1016/0896-6273(94)90421-9.
5
Sympathetic neuroblasts undergo a developmental switch in trophic dependence.交感神经母细胞在营养依赖方面经历了发育转变。
Development. 1993 Nov;119(3):597-610. doi: 10.1242/dev.119.3.597.
6
NGF and neurotrophin-3 both activate TrkA on sympathetic neurons but differentially regulate survival and neuritogenesis.神经生长因子（NGF）和神经营养素-3均能激活交感神经元上的酪氨酸激酶受体A（TrkA），但对细胞存活和神经突生成的调节存在差异。
J Cell Biol. 1997 Jan 27;136(2):375-88. doi: 10.1083/jcb.136.2.375.
7
Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions.神经营养因子及其受体在感觉神经节和交感神经节中的神经元和非神经元表达提示了新的细胞间营养相互作用。
J Comp Neurol. 1995 Feb 27;353(1):143-59. doi: 10.1002/cne.903530113.
8
Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets.神经营养因子-3在产前和产后对交感神经母细胞存活及特定靶器官神经支配的需求。
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9
Effects of ciliary neurotrophic factor on the survival and response to nerve growth factor of cultured rat sympathetic neurons.睫状神经营养因子对培养的大鼠交感神经元存活及对神经生长因子反应的影响。
Dev Biol. 1994 Jan;161(1):96-106. doi: 10.1006/dbio.1994.1012.
10
Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues.神经营养因子（NGF、BDNF、NT - 3和GDNF）及其受体（p75NGFR、trkA、trkB和trkC）在成人人外周神经系统和非神经组织中的mRNA表达。
Neurochem Res. 1996 Aug;21(8):929-38. doi: 10.1007/BF02532343.

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ErbB4 activation inhibits MPP+-induced cell death in PC12-ErbB4 cells: involvement of PI3K and Erk signaling.ErbB4激活抑制MPP⁺诱导的PC12-ErbB4细胞死亡：PI3K和Erk信号通路的参与
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Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear.成年螺旋神经节神经元的存活需要内耳中的erbB受体信号传导。
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本文引用的文献

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Specific high-affinity receptors for neurotrophin-3 on sympathetic neurons.交感神经元上神经营养因子-3的特异性高亲和力受体。
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ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family.ARIA是一种刺激乙酰胆碱受体合成的蛋白质，是神经配体家族的成员。
Cell. 1993 Mar 12;72(5):801-15. doi: 10.1016/0092-8674(93)90407-h.
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p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins.p75基因缺陷的三叉神经感觉神经元对神经生长因子（NGF）的反应发生改变，但对其他神经营养因子无此现象。
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The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development.CNTF受体的α亚基对于信号传导是必需的，并确定了成年期和发育过程中潜在的CNTF靶标。
Neuron. 1993 Jan;10(1):89-102. doi: 10.1016/0896-6273(93)90245-m.
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Disruption of the CNTF gene results in motor neuron degeneration.睫状神经营养因子基因的破坏导致运动神经元变性。
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Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development.在小鼠发育过程中，神经调节蛋白的不同亚型在间充质细胞和神经元细胞中表达。
Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1064-8. doi: 10.1073/pnas.91.3.1064.
8
Severe sensory and sympathetic deficits in mice lacking neurotrophin-3.缺乏神经营养因子-3的小鼠出现严重的感觉和交感神经功能缺陷。
Nature. 1994 Jun 23;369(6482):658-61. doi: 10.1038/369658a0.
9
Regulation of expression of mRNAs encoding the nerve growth factor receptors p75 and trkA in developing sensory neurons.发育中的感觉神经元中编码神经生长因子受体p75和trkA的mRNA表达调控。
Development. 1993 Nov;119(3):635-48. doi: 10.1242/dev.119.3.635.
10
Sympathetic neuroblasts undergo a developmental switch in trophic dependence.交感神经母细胞在营养依赖方面经历了发育转变。
Development. 1993 Nov;119(3):597-610. doi: 10.1242/dev.119.3.597.

由NT-3和神经调节蛋白介导的双向细胞间相互作用控制着交感神经母细胞的早期存活和发育。

A reciprocal cell-cell interaction mediated by NT-3 and neuregulins controls the early survival and development of sympathetic neuroblasts.

作者信息

Verdi J M, Groves A K, Fariñas I, Jones K, Marchionni M A, Reichardt L F, Anderson D J

机构信息

Division of Biology 216-76, California Institute of Technology, Pasadena 91125, USA.

出版信息

Neuron. 1996 Mar;16(3):515-27. doi: 10.1016/s0896-6273(00)80071-9.

DOI:10.1016/s0896-6273(00)80071-9
PMID:8785049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2711899/
Abstract

Neurotrophin 3 (NT-3) can support the survival of some embryonic sympathetic neuroblasts before they become nerve growth factor dependent. We show that NT-3 is produced in vivo by nonneuronal cells neighboring embryonic sympathetic ganglia. NT-3 mRNA is produced by these nonneuronal cells in vitro and is up-regulated by platelet-derived growth factor, ciliary neurotrophic factor, and glial growth factor 2 (a neuregulin). Nonneuronal cell-conditioned medium promotes survival and induces TrkA expression in isolated sympathetic neuroblasts, and this activity is blocked by anti-NT-3 antibody. Neuroblasts also enhance NT-3 production by nonneural cells. Neuroblasts synthesize several forms of neuregulin, and antibodies to neuregulin attenuate the effect of the neuroblasts on the nonneuronal cells. These data suggest a reciprocal cell-cell interaction, in which neuroblast-derived neuregulins promote NT-3 production by neighboring nonneuronal cells, which in turn promotes neuroblast survival and further differentiation.

摘要

神经营养因子3（NT-3）能够在某些胚胎交感神经母细胞变得依赖神经生长因子之前，支持它们的存活。我们发现，NT-3在体内由胚胎交感神经节附近的非神经元细胞产生。这些非神经元细胞在体外可产生NT-3 mRNA，并且血小板衍生生长因子、睫状神经营养因子和神经胶质生长因子2（一种神经调节蛋白）可使其上调。非神经元细胞条件培养基可促进分离出的交感神经母细胞的存活并诱导TrkA表达，而这种活性可被抗NT-3抗体阻断。神经母细胞也会增强非神经细胞的NT-3产生。神经母细胞可合成多种形式的神经调节蛋白，而针对神经调节蛋白的抗体可减弱神经母细胞对非神经元细胞的作用。这些数据表明存在一种相互的细胞间相互作用，即神经母细胞衍生的神经调节蛋白促进相邻非神经元细胞产生NT-3，而NT-3反过来又促进神经母细胞的存活和进一步分化。