Griffiths T W, Griffiths C E, Voorhees J J
Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314, USA.
Dermatol Clin. 1995 Oct;13(4):739-49.
Overwhelming evidence exists supporting the importance of T-lymphocytes and other immunologically competent cells in the pathogenesis of psoriasis. What is still uncertain, however, is whether the keratinocyte plays an initiating role in its own hyperproliferation. Studies at the basic science level have allowed us to identify various cellular and molecular events that the immunopharmacologist can target with a variety of approaches. At present, the most selective immunosuppressant available is cyclosporine. As rapid strides are made toward further elucidation of the immunopathogenesis of psoriasis, more highly selective approaches are fast becoming a reality.
大量证据支持T淋巴细胞和其他免疫活性细胞在银屑病发病机制中的重要性。然而，仍不确定的是角质形成细胞是否在其自身的过度增殖中起启动作用。基础科学层面的研究使我们能够识别免疫药理学家可以通过多种方法靶向的各种细胞和分子事件。目前，可用的最具选择性的免疫抑制剂是环孢素。随着在进一步阐明银屑病免疫发病机制方面取得快速进展，更具高度选择性的方法正迅速成为现实。
