Barker J N
Therapy Research Unit, St John's Institute of Dermatology, St Thomas' Hospital, London.
Hosp Med. 1998 Jul;59(7):530-3.
Psoriasis is a common chronic skin disease in which T lymphocytes are thought to play a vital pathogenic role. Evidence shows that these are activated memory skin-homing T cells which induce characteristic disease features via cytokine production. Understanding the mechanisms of T cell accumulation in skin and mediation of psoriasis is critical to designing immunotherapy for this distressing disease.
银屑病是一种常见的慢性皮肤病，其中T淋巴细胞被认为起着至关重要的致病作用。证据表明，这些是活化的记忆性皮肤归巢T细胞，它们通过产生细胞因子诱导特征性的疾病特征。了解T细胞在皮肤中积聚以及介导银屑病的机制对于设计针对这种令人苦恼疾病的免疫疗法至关重要。
