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Halistanol disulfate B, a novel sulfated sterol from the sponge Pachastrella sp.: inhibitor of endothelin converting enzyme.

作者信息

Patil A D, Freyer A J, Breen A, Carte B, Johnson R K

机构信息

Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, Research and Development, King of Prussia, Pennsylvania 19406-0939, USA.

出版信息

J Nat Prod. 1996 Jun;59(6):606-8. doi: 10.1021/np9601770.

DOI:10.1021/np9601770
PMID:8786367
Abstract

As part of a search for novel inhibitors of endothelin converting enzyme (ECE), the MeOH extract of a South African sponge, Pachastrella sp., was shown to be active. Bioassay-guided fractionation of the extract yielded a novel sterol sulfate, halistanol disulfate B (1). The structure and stereochemistry of 1 was established mainly by interpretation of spectral data. Disulfate (1) was found to be active at a micromolar concentration in the ECE assay.

摘要

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