Islam Md Rezaul, Dhar Puja Sutro, Akash Shopnil, Syed Sabeena Hussain, Gupta Jeetendra Kumar, Gandla Kumaraswamy, Akter Muniya, Rauf Abdur, Hemeg Hassan A, Anwar Yasir, Aljohny Bassam Oudh, Wilairatana Polrat
Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Daffodil Smart City, Birulia, Savar, Dhaka, 1216, Bangladesh.
School of Pharmacy, Vishwakarma University, Survey No 2, 3,4, Kondhwa Main Rd, Laxmi Nagar, Betal Nagar, Kondhwa, Pune, Maharashtra, 411048, India.
Nat Prod Bioprospect. 2023 Oct 30;13(1):45. doi: 10.1007/s13659-023-00411-1.
Hypertension (HTN), a complex cardiovascular disease (CVD), significantly impacts global health, prompting a growing interest in complementary and alternative therapeutic approaches. This review article seeks to provide an up-to-date and thorough summary of modern therapeutic techniques for treating HTN, with an emphasis on the molecular mechanisms of action found in substances found in plants, herbs, and seafood. Bioactive molecules have been a significant source of novel therapeutics and are crucial in developing and testing new HTN remedies. Recent advances in science have made it possible to understand the complex molecular mechanisms underlying blood pressure (BP)-regulating effects of these natural substances better. Polyphenols, flavonoids, alkaloids, and peptides are examples of bioactive compounds that have demonstrated promise in influencing several pathways involved in regulating vascular tone, reducing oxidative stress (OS), reducing inflammation, and improving endothelial function. The article explains the vasodilatory, diuretic, and renin-angiotensin-aldosterone system (RAAS) modifying properties of vital plants such as garlic and olive leaf. Phytochemicals from plants are the primary in traditional drug development as models for novel antihypertensive drugs, providing diverse strategies to combat HTN due to their biological actions. The review also discusses the functions of calcium channel blockers originating from natural sources, angiotensin-converting enzyme (ACE) inhibitors, and nitric oxide (NO) donors. Including seafood components in this study demonstrates the increased interest in using bioactive chemicals originating from marine sources to treat HTN. Omega-3 fatty acids, peptides, and minerals obtained from seafood sources have anti-inflammatory, vasodilatory, and antioxidant properties that improve vascular health and control BP. Overall, we discussed the multiple functions of bioactive molecules and seafood components in the treatment of HTN.
高血压（HTN）是一种复杂的心血管疾病（CVD），对全球健康有重大影响，这促使人们对补充和替代治疗方法的兴趣日益增加。这篇综述文章旨在提供关于治疗高血压的现代治疗技术的最新和全面总结，重点是植物、草药和海鲜中发现的物质的分子作用机制。生物活性分子一直是新型治疗方法的重要来源，在开发和测试新的高血压治疗药物中起着关键作用。科学上的最新进展使人们能够更好地理解这些天然物质调节血压（BP）作用背后的复杂分子机制。多酚、黄酮类化合物、生物碱和肽等生物活性化合物已显示出有望影响调节血管张力、减少氧化应激（OS）、减轻炎症和改善内皮功能的多种途径。文章解释了大蒜和橄榄叶等重要植物的血管舒张、利尿和肾素-血管紧张素-醛固酮系统（RAAS）调节特性。植物中的植物化学物质是传统药物开发中新型抗高血压药物模型的主要来源，由于其生物学作用，为对抗高血压提供了多种策略。综述还讨论了天然来源的钙通道阻滞剂、血管紧张素转换酶（ACE）抑制剂和一氧化氮（NO）供体的作用。本研究纳入海鲜成分表明，人们越来越有兴趣利用海洋来源的生物活性化学物质来治疗高血压。从海鲜中获得的ω-3脂肪酸、肽和矿物质具有抗炎、血管舒张和抗氧化特性，可改善血管健康并控制血压。总体而言，我们讨论了生物活性分子和海鲜成分在高血压治疗中的多种作用。
