A two-step efficient chemoenzymatic synthesis of flavonoid glycoside malonates.

A simple and high-yielding protocol for the malonylation of some flavonoid glycosides is described. The two-step synthesis is based on the regioselective enzymatic introduction of a benzylmalonyl group by catalysis with the lipase from Candida antarctica, followed by Pd/C hydrogenolysis of the benzyl moiety.