School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Molecules. 2010 Dec 10;15(12):9174-83. doi: 10.3390/molecules15129174.
A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, 1H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents.
一组新型的桃儿七皂苷衍生物被合成。通过它们的红外光谱（IR）、1H-NMR 和质谱（MS）谱图分析鉴定了这些衍生物的结构。在胰岛素抵抗（IR）HepG2 细胞模型上评估了它们的抗糖尿病活性。结果表明，与阳性对照药（二甲双胍）相比，化合物 7a、7c、7h 和桃儿七皂苷在 IR-HepG2 细胞中具有显著的增强葡萄糖消耗作用。这项研究为进一步设计和发现抗糖尿病药物提供了有用的线索。
