反式柳叶菜苷衍生物的合成及生物活性研究作为有效的抗糖尿病药物。
Synthesis and biological activity of trans-tiliroside derivatives as potent anti-diabetic agents.
机构信息
School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
出版信息
Molecules. 2010 Dec 10;15(12):9174-83. doi: 10.3390/molecules15129174.
A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, 1H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents.
一组新型的桃儿七皂苷衍生物被合成。通过它们的红外光谱（IR）、1H-NMR 和质谱（MS）谱图分析鉴定了这些衍生物的结构。在胰岛素抵抗（IR）HepG2 细胞模型上评估了它们的抗糖尿病活性。结果表明，与阳性对照药（二甲双胍）相比，化合物 7a、7c、7h 和桃儿七皂苷在 IR-HepG2 细胞中具有显著的增强葡萄糖消耗作用。这项研究为进一步设计和发现抗糖尿病药物提供了有用的线索。
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