Takeda N, Hasegawa S, Morita M, Horii A, Uno A, Yamatodani A, Matsunaga T
Department of Otolaryngology, Osaka University Medical School, Japan.
Methods Find Exp Clin Pharmacol. 1995 Nov;17(9):589-90.
The effects of diphenhydramine, domperidone, ondansetron, and diphenidol on motion- and apomorphine-induced pica (i.e., kaolin ingestion) in rats as the measure analogous to emesis in other species were examined. Diphenhydramine (10 and 20 mg/kg) and diphenidol (30 mg/kg) inhibited kaolin intake induced by 60-min double rotation, while domperidone and ondansetron did not. Kaolin intake induced by apomorphine (10 mg/kg) was inhibited by domperidone (2 mg/kg) and diphenidol (30 mg/kg), but not by diphenhydramine or ondansetron. These findings suggest that the emetic pathways through the inner ear (double rotation) and the chemoreceptor trigger zone (apomorphine) are pharmacologically independent and are mediated by histamine H1 receptors and dopamine D2 receptors, respectively. Diphenidol may inhibit a common locus of emesis.
研究了苯海拉明、多潘立酮、昂丹司琼和地芬尼多对大鼠运动及阿扑吗啡诱导的异食癖（即高岭土摄取）的影响，以此作为类似于其他物种呕吐的指标。苯海拉明（10和20mg/kg）和地芬尼多（30mg/kg）抑制60分钟双旋转诱导的高岭土摄取，而多潘立酮和昂丹司琼则无此作用。阿扑吗啡（10mg/kg）诱导的高岭土摄取被多潘立酮（2mg/kg）和地芬尼多（30mg/kg）抑制，但不受苯海拉明或昂丹司琼的影响。这些发现表明，通过内耳（双旋转）和化学感受器触发区（阿扑吗啡）的催吐途径在药理学上是独立的，分别由组胺H1受体和多巴胺D2受体介导。地芬尼多可能抑制呕吐的共同位点。
