Sever I S
Mol Gen Mikrobiol Virusol. 1996 Jan-Mar(1):23-6.
Three isogenic Y. pseudotuberculosis strains were studied. One of them contained pVM82 plasmid which was found in foci of pseudotuberculosis outbreaks and increased Yersinia resistance to blood serum. Cells with pVM82 plasmid did not inhibit the activation of complement components C1, C2, C3, C4, and C5 in human serum and increased the consumption of these complement components in comparison with control strains. Y. pseudotuberculosis cells with pVM82 were better resistant to human neutrophil phagocytosis than bacterial cells without this plasmid. For the strain with pVM82 plasmid, a lower level of phagocytosis within the first 30 min of Y. pseudotuberculosis incubation with neutrophils and a reduced percentage of killed bacteria among all those phagocytosed over the entire period of incubation of bacteria with neutrophils were observed.
研究了三株同基因的假结核耶尔森氏菌菌株。其中一株含有pVM82质粒，该质粒在假结核爆发病灶中被发现，可增强耶尔森氏菌对血清的抗性。与对照菌株相比，携带pVM82质粒的细胞不会抑制人血清中补体成分C1、C2、C3、C4和C5的激活，且会增加这些补体成分的消耗。携带pVM82的假结核耶尔森氏菌细胞比没有该质粒的细菌细胞对人中性粒细胞吞噬作用的抗性更强。对于携带pVM82质粒的菌株，在假结核耶尔森氏菌与中性粒细胞孵育的前30分钟内观察到较低水平的吞噬作用，并且在细菌与中性粒细胞孵育的整个期间内，在所有被吞噬的细菌中，被杀灭细菌的百分比降低。
