Szutowicz A, Tomaszewicz M, Bielarczyk H
Department of Clinical Biochemistry, Medical University of Gdańsk, Poland.
Acta Neurobiol Exp (Wars). 1996;56(1):323-39. doi: 10.55782/ane-1996-1137.
Acetyl-CoA provision to the synaptoplasmic compartment of cholinergic nerve terminals plays a regulatory role in the synthesis of acetylcholine. The disturbances in glucose utilization and in decarboxylation of the end product of its metabolism pyruvate, are considered to be significant factors causing cholinergic deficits in several diseases of the central nervous system. In this article we review data concerning role of acetyl-CoA in patomechanisms of disturbances of cholinergic metabolism in Alzheimers disease, thiamine deficiency, inherited defects of pyruvate dehydrogenase and diabetes.
向胆碱能神经末梢的突触质区室提供乙酰辅酶A在乙酰胆碱的合成中起调节作用。葡萄糖利用以及其代谢终产物丙酮酸脱羧过程中的紊乱被认为是导致中枢神经系统多种疾病中胆碱能缺陷的重要因素。在本文中，我们综述了有关乙酰辅酶A在阿尔茨海默病、硫胺素缺乏、丙酮酸脱氢酶遗传性缺陷和糖尿病中胆碱能代谢紊乱发病机制中的作用的数据。
