头孢噻吩对松动髋关节假体周围基质金属蛋白酶活性的抑制作用。
Inhibitory effect of cephalothin on matrix metalloproteinase activity around loose hip prostheses.
作者信息
Santavirta S, Takagi M, Konttinen Y T, Sorsa T, Suda A
机构信息
Invalid Foundation, ORTON Orthopedic Hospital, Helsinki, Finland.
出版信息
Antimicrob Agents Chemother. 1996 Jan;40(1):244-6. doi: 10.1128/AAC.40.1.244.
Abstract
The inhibitory effects of drugs on matrix metalloproteinase (MMP) activity in tissues around sites of loose total hip arthroplasty (THA) prostheses were studied. For activity measurements, a DNP-S (dinitrophenyl-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg) peptide degradation assay was performed by means of high-performance liquid chromatography. Neutral salt tissue extracts revealed significantly elevated MMP activity in THA samples compared with that in noninflamed synovial tissue from the knee joint. This elevation was markedly inhibited by cephalothin, but not by doxycycline, tetracycline, or gentamicin. These results indicate that cephalothin can inhibit MMP activity in reactive periprosthetic tissue and thus reduce, by a nonantimicrobial mechanism, the tissue destruction associated with the loosening of THA implants.
摘要
研究了药物对全髋关节置换术（THA）假体松动部位周围组织中基质金属蛋白酶（MMP）活性的抑制作用。为了进行活性测量，通过高效液相色谱法进行了DNP-S（二硝基苯基-脯氨酸-谷氨酰胺-甘氨酸-异亮氨酸-丙氨酸-甘氨酸-谷氨酰胺-D-精氨酸）肽降解测定。中性盐组织提取物显示，与膝关节非炎性滑膜组织相比，THA样本中的MMP活性显著升高。头孢噻吩可显著抑制这种升高，但强力霉素、四环素或庆大霉素则无此作用。这些结果表明，头孢噻吩可抑制假体周围反应性组织中的MMP活性，从而通过非抗菌机制减少与THA植入物松动相关的组织破坏。
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