Winand R J, Winand-Devigne J, Cox C, Caulier C, Meurisse M
Thyroid Unit, CHU, Sart-Tilman, Belgium.
J Endocrinol Invest. 1995 Nov;18(10):749-53. doi: 10.1007/BF03349806.
Two radioimmunological techniques for the measurement of anti-alpha-galactosyl (anti-Gal) antibodies were developed and we demonstrated that this antibody is present in the serum of most untreated patients with Graves' disease, thyroid-associated ophthalmopathy (TAO) and autoimmune thyroiditis. Thyrotropin-binding inhibiting immunoglobulins (TBII) and Thyroid Stimulating Antibodies (TSAb) are frequently found in serum of patients with Graves' disease but not with autoimmune thyroiditis. Although TBII and anti-Gal were found sometimes simultaneously in the same serum samples, we demonstrated that anti-Gal could be present in the absence of TBII and reciprocally.
我们开发了两种用于测量抗α-半乳糖基（抗Gal）抗体的放射免疫技术，并且我们证明这种抗体存在于大多数未经治疗的格雷夫斯病、甲状腺相关性眼病（TAO）和自身免疫性甲状腺炎患者的血清中。促甲状腺素结合抑制性免疫球蛋白（TBII）和甲状腺刺激抗体（TSAb）经常在格雷夫斯病患者的血清中发现，但在自身免疫性甲状腺炎患者的血清中未发现。尽管有时在同一血清样本中同时发现TBII和抗Gal，但我们证明抗Gal可以在没有TBII的情况下存在，反之亦然。
