利用同胞风险比和遗传方差成分来表征模拟的寡基因疾病。

Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease.

作者信息

Almasy L, Tierney C, Risch N

机构信息

Department of Genetics, Yale University, New Haven, Connecticut, USA.

出版信息

Genet Epidemiol. 1995;12(6):565-70. doi: 10.1002/gepi.1370120607.

DOI:10.1002/gepi.1370120607

PMID:8787974

Abstract

Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed.

摘要

同胞风险比用于量化两个模拟疾病位点的遗传效应，这些位点通过传递不平衡检验（TDT）和关联方法识别，并通过从相对外显率矩阵导出的方差分量进行表征。还讨论了数据集与模拟模型之间的不一致性。