Dizier M H, Babron M C, Clerget-Darpoux F
INSERM U155, Paris, France.
Genet Epidemiol. 1995;12(6):589-93. doi: 10.1002/gepi.1370120611.
Two susceptibility genes, in linkage disequilibrium with alleles of the markers D1G31 and D5G23, have been identified for the disease in the simulated data set of Problem 1. Here we apply the MASC (marker association segregation chi-square) method to model the joint effect of these two genes, by testing two-locus models. The model we obtain, that is the most parsimonious and that best fits the data, corresponds to a direct involvement of the alleles D1G31-8 and D5G23-7, with a nonmultiplicative effect of the two alleles. This was indeed assumed in the true model used for simulating the data.
在问题1的模拟数据集中，已鉴定出与标记D1G31和D5G23的等位基因处于连锁不平衡状态的两个易感基因。在此，我们应用MASC（标记关联分离卡方）方法，通过测试双位点模型来模拟这两个基因的联合效应。我们得到的模型是最简约且最符合数据的，它对应于等位基因D1G31 - 8和D5G23 - 7的直接参与，且这两个等位基因具有非乘性效应。这确实是在用于模拟数据的真实模型中所假设的。
