Suarez B K, Hampe C L, O'Rourke D, Van Eerdewegh P, Reich T
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Genet Epidemiol. 1995;12(6):675-80. doi: 10.1002/gepi.1370120626.
Association and transmission/nontransmission analyses were used in a split sample design to identify disease susceptibility alleles at two loci. Sib-pair analysis on various subsets of the data identified an additional four regions that yielded signals of disease predisposing quantitative trait loci (QTLs). Three of these four regions represented Type I errors. A new simulation indicates that a multiplex sampling strategy would substantially improve QTL detection for this oligogenic transmission model.
关联分析以及传递/非传递分析被用于一种拆分样本设计中，以识别两个位点处的疾病易感性等位基因。对数据的各个子集进行的同胞对分析确定了另外四个区域，这些区域产生了疾病易感数量性状基因座（QTL）的信号。这四个区域中的三个代表了I型错误。一项新的模拟表明，多重抽样策略将显著提高这种寡基因传递模型的QTL检测能力。
