Klein S, Miles J
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110-1093, USA.
JPEN J Parenter Enteral Nutr. 1996 Jan-Feb;20(1):13-9. doi: 10.1177/014860719602000113.
The 1995 A.S.P.E.N. Research Workshop was held at the annual meeting in Miami Beach, Florida, on January 15, 1995. The workshop focused on substrate metabolism in humans.
State-of-the-art presentations on the regulation of energy, carbohydrate, lipid, and protein metabolism during health and disease were made by the preeminant leaders in the field. The presentations concentrated on in vivo studies performed in humans and included both recently published and unpublished data.
Using sophisticated research methodology, such as nuclear magnetic resonance spectroscopy, compartmental modeling, stable isotope tracers, microdialysis, and abdominal vein catheterization, the investigators presented data that clarified unresolved issues, challenged many previously held dogmas, and raised new questions for future investigations in human intermediary metabolism.
This workshop demonstrated that in vivo investigation remains the best approach for providing physiologically relevant data in humans. An understanding of normal human physiology and the metabolic alterations caused by disease is critical for optimal nutritional and metabolic management of patients.
1995年美国肠外肠内营养学会（A.S.P.E.N.）研究研讨会于1995年1月15日在佛罗里达州迈阿密海滩举行的年会上召开。该研讨会聚焦于人类的底物代谢。
该领域的杰出领军人物就健康和疾病状态下能量、碳水化合物、脂质及蛋白质代谢的调节进行了前沿进展报告。报告集中于在人体进行的体内研究，包括近期已发表和未发表的数据。
研究人员运用了先进的研究方法，如核磁共振波谱法、房室模型、稳定同位素示踪剂、微透析和腹静脉插管法，展示的数据澄清了未解决的问题，挑战了许多先前的教条，并为人类中间代谢的未来研究提出了新问题。
本次研讨会表明，体内研究仍然是为人类提供生理相关数据的最佳方法。了解正常人体生理学以及疾病引起的代谢改变对于患者的最佳营养和代谢管理至关重要。
