Winter P, Ganter K, Leppin U, Schoeneich G, Hesse A
Department of Urology, University of Bonn, Germany.
Urol Res. 1995;23(6):401-5. doi: 10.1007/BF00698743.
In 50 calcium oxalate stone-forming patients, the total excretion of glycosaminoglycans (GAGs) and of four subgroups [chondroitin-4-sulfate (CS-A), chondroitin-6-sulfate (CS-C), dermatan sulfate (DS) and hyaluronic acid (HY)] were investigated before extracorporeal shock wave lithotripsy (ESWL) and during the subsequent 5 days. The standard value was determined by reference to a group of healthy test subjects. The excretion of GAGs was significantly higher in healthy test persons than in stone-forming patients. Twenty-four hours after ESWL administration, GAG excretion was enhanced significantly but returned to normal values over the course of 3 days. ESWL had no influence on the proportional composition of GAG subgroups CS-A, CS-C, DS and HY. The increase in GAG excretion after ESWL indicates a transient injury of renal tissue or of the mucus layer lining the urothelium. This lesion, however, can be regarded as temporary with later restitutio ad integrum.
在50例草酸钙结石形成患者中，在体外冲击波碎石术（ESWL）前及随后5天内，对糖胺聚糖（GAGs）及其四个亚组[硫酸软骨素-4（CS-A）、硫酸软骨素-6（CS-C）、硫酸皮肤素（DS）和透明质酸（HY）]的总排泄量进行了研究。通过参考一组健康受试对象确定标准值。健康受试者中GAGs的排泄量显著高于结石形成患者。ESWL治疗24小时后，GAG排泄量显著增加，但在3天内恢复到正常水平。ESWL对GAG亚组CS-A、CS-C、DS和HY的比例组成没有影响。ESWL后GAG排泄量的增加表明肾组织或尿路上皮衬里黏液层有短暂损伤。然而，这种损伤可被视为暂时的，随后可完全恢复。
