Feuerstein C, Tanche M, Serre F, Gavend M, Pellat J, Perret J
Acta Neurol Scand. 1977 Jul;56(1):79-82. doi: 10.1111/j.1600-0404.1977.tb01411.x.
Clinically scored levodopa-induced dyskinesias were correlated with plasma dopa and O-methyl-dopa levels determined every hour during one day in 30 Parkinsonian-treated patients. In patients treated with a combination of L-dopa and a peripheral decarboxylase inhibitor (PDI), those with dyskinesias have very high plasma O-methyl-dopa levels compared with those who have no dyskinesias. In contrast, no significantly different plasma dopa levels are found in these two subgroups of patients, leaving open the question of the possible involvement of such elevated plasma O-methyl-dopa levels in favouring dyskinesias.
对30例接受帕金森病治疗的患者进行临床评分，评估左旋多巴诱发的异动症，并与一天中每小时测定的血浆多巴和O-甲基多巴水平进行相关性分析。在接受左旋多巴和外周脱羧酶抑制剂（PDI）联合治疗的患者中，出现异动症的患者与未出现异动症的患者相比，血浆O-甲基多巴水平非常高。相比之下，在这两组患者亚组中未发现血浆多巴水平有显著差异，这使得血浆O-甲基多巴水平升高可能与异动症有关这一问题仍未解决。
