Skjaeraasen J, Maltau J M
Acta Obstet Gynecol Scand. 1977;56(3):179-83. doi: 10.3109/00016347709162117.
In a material of 144 samples of amniotic fluid from the last trimester, creatinine concentration, lecithin/sphingomyelin (L/S) ration and their correlation, have been examined. Amniotic fluid creatinine concentration (a.f.c.) increased gradually through the last trimester up to 39 weeks (273-279 days p.m.) with median values of 2 mg/100 ml at 37 weeks and 2.5 mg/100 ml at 39 weeks gestation. The great range makes a.f.c. of doubtful value in assessment of gestional age in individual samples. The correlation between a.f.c. and L/S ratio was highly significant (Kendall's T=0.56). Even so lung maturity cannot be predicted from a.f.c. A low L/S ratio with a.f.c. larger than or equal to 2 mg/100 ml was found in 8-9%, while a.f.c. 1.1-1.9 mg/100 ml was combined with L/S ratios larger then or equal to 2 in a great number of cases. A.f.c. less than 1.1 mg/100 ml was invariably correlated with low L/S ratios.
对144份孕晚期羊水样本的材料进行了肌酐浓度、卵磷脂/鞘磷脂（L/S）比值及其相关性检测。羊水肌酐浓度（a.f.c.）在孕晚期逐渐升高，直至39周（妊娠273 - 279天），37周时中位数为2mg/100ml，39周妊娠时为2.5mg/100ml。较大的范围使得a.f.c.在评估单个样本的胎龄时价值存疑。a.f.c.与L/S比值之间的相关性非常显著（肯德尔T = 0.56）。即便如此，也无法根据a.f.c.预测肺成熟度。发现8 - 9%的病例中L/S比值低而a.f.c.大于或等于2mg/100ml，而在大量病例中a.f.c.为1.1 - 1.9mg/100ml时L/S比值大于或等于2。a.f.c.小于1.1mg/100ml总是与低L/S比值相关。
