Bender C M, Monti E J, Kerr M E
University of Pittsburgh, School of Nursing, Pennsylvania 15261, USA.
Cancer Pract. 1996 Jan-Feb;4(1):35-9.
This article examines potential mechanisms underlying the neurologic toxicities associated with interferon therapy in patients with cancer. The following mechanisms for interferon-related toxicities have been proposed: changes in certain neuroendocrine hormone levels; structural similarities and common pathways between interferon and specific neuroendocrine hormones; and the immunoregulatory effects of interferon. Strategies for the assessment and management of interferon-related neurologic toxicities are discussed. A reduction in dose or discontinuation of interferon may be recommended if interferon neurotoxicity develops. Additional interventions may include reorientation strategies, provision of uninterrupted periods of rest, and safety precautions. Directions for future research are recommended.
本文探讨了癌症患者中与干扰素治疗相关的神经毒性潜在机制。已提出以下与干扰素相关毒性的机制：某些神经内分泌激素水平的变化；干扰素与特定神经内分泌激素之间的结构相似性和共同途径；以及干扰素的免疫调节作用。讨论了评估和管理与干扰素相关神经毒性的策略。如果出现干扰素神经毒性，可能建议减少剂量或停用干扰素。其他干预措施可能包括重新定向策略、提供不间断的休息时间以及安全预防措施。还推荐了未来研究的方向。
