Armstrong T, Rust D, Kohtz J R
Department of Neurology, Emory University Hospital, Atlanta, GA, USA.
Oncol Nurs Forum. 1997 Jan-Feb;24(1 Suppl):23-33.
PURPOSE/OBJECTIVES: To discuss dose-intensive chemotherapy and the associated toxicities to the nervous, pulmonary, and cutaneous systems.
Published articles, book chapters, and personal experience.
Because of the discovery of the protective effect of colony stimulating factors, a renewed emphasis has been placed on dose-intensive chemotherapy in an attempt to affect both survival and cure rates with chemotherapy. As a result, increased toxicities have been seen in other organ systems.
Toxicities to the nervous, pulmonary, and cutaneous systems are increasing. Meticulous medical and nursing care are critical to ensure patient survival and to minimize these effects.
Goals of care include a through knowledge of potential toxicities, recognition of signs and symptoms of toxicity, and appropriate nursing interventions once such deficits occur to decrease the toxic effects of chemotherapy and improve patient function.
目的/目标：探讨剂量密集化疗及其对神经、肺和皮肤系统的相关毒性。
发表的文章、书籍章节及个人经验。
由于发现了集落刺激因子的保护作用，人们重新重视剂量密集化疗，试图通过化疗提高生存率和治愈率。结果，其他器官系统出现了更多的毒性反应。
对神经、肺和皮肤系统的毒性反应正在增加。精心的医疗和护理对于确保患者存活及将这些影响降至最低至关重要。
护理目标包括全面了解潜在毒性、识别毒性的体征和症状，以及一旦出现此类缺陷时采取适当的护理干预措施，以减轻化疗的毒性作用并改善患者功能。
