Rashidy-Pour A, Motaghed-Larijani Z, Bures J
Institute of Physiology, Academy of Sciences, Prague, Czech Republic.
Behav Brain Res. 1995 Dec 14;72(1-2):185-8. doi: 10.1016/0166-4328(96)00136-2.
Involvement of the medial septal area (MSA) in consolidation and retrieval of passive avoidance response (PAR) was investigated with functional suppression of this area by tetrodotoxin (TTX). Rats carrying a chronically implanted cannula aimed at the MSA were trained on a step-through passive avoidance task and received intraseptal injection of 5 ng TTX dissolved in 1 microliter saline 5, 90 and 360 min after the acquisition trial or 60 min before the retrieval test. TTX injected 5 and 90 min after the acquisition trial significantly reduced avoidance of the dark compartment in comparison with the control group injected with saline. PAR was not impaired by septal TTX injected 360 min after acquisition or 60 min before the retrieval test. Step-through latency of naive rats was not affected by septal blockade. The results indicate that the MSA contributes to PAR consolidation at least 90 min after acquisition but its involvement in PAR retrieval is unlikely. It is concluded that functional ablation of the MSA may disrupt integrity of subcortical circuits participating in PAR learning.
通过河豚毒素（TTX）对内侧隔区（MSA）进行功能抑制，研究了该区域在被动回避反应（PAR）巩固和检索中的作用。将携带长期植入针对MSA的套管的大鼠进行穿梭箱被动回避任务训练，并在获得性试验后5、90和360分钟或检索测试前60分钟，向隔区内注射溶解于1微升盐水中的5纳克TTX。与注射生理盐水的对照组相比，在获得性试验后5分钟和90分钟注射TTX显著降低了对黑暗隔室的回避。在获得后360分钟或检索测试前60分钟注射隔区TTX，PAR未受损。幼稚大鼠的穿梭潜伏期不受隔区阻断的影响。结果表明，MSA在获得后至少90分钟对PAR巩固有贡献，但它不太可能参与PAR检索。得出的结论是，MSA的功能消融可能会破坏参与PAR学习的皮层下回路的完整性。
