Kirkwood K S, Debas H T
School of Medicine, University of California, San Francisco 94143-0410, USA.
Compr Ther. 1995 Dec;21(12):719-25.
In recent decades, isolation of the peptides secreted by gastrointestinal neuroendocrine tumors has greatly advanced our understanding of the pathophysiology of the syndromes resulting from over-production of these biologically active compounds. Early detection of these lesions permits localization and surgical extirpation prior to the development of mestastatic disease. In 1995, early detection of gastrointestinal neuroendocrine tumors hinges on an appropriate index of suspicion on the part of the primary care physician. The prompt recognition of the typical clinical constellations of symptoms associated with these tumors is essential to their timely diagnosis and management.
近几十年来，胃肠道神经内分泌肿瘤分泌的肽类物质的分离极大地推进了我们对这些生物活性化合物产生过多所导致综合征病理生理学的理解。这些病变的早期检测能够在转移性疾病发生之前进行定位和手术切除。1995年，胃肠道神经内分泌肿瘤的早期检测取决于初级保健医生是否有适当的怀疑指数。迅速识别与这些肿瘤相关的典型临床症状组合对于其及时诊断和管理至关重要。
