Pahor M, Guralnik J M, Havlik R J, Carbonin P, Salive M E, Ferrucci L, Corti M C, Hennekens C H
Department of Internal Medicine and Geriatrics, Catholic University, Rome, Italy.
J Am Geriatr Soc. 1996 Sep;44(9):1030-7. doi: 10.1111/j.1532-5415.1996.tb02933.x.
To assess whether low to moderate alcohol consumption decreases the risk of deep venous thrombosis and pulmonary embolism.
Prospective cohort study.
Three communities of the Established Populations for Epidemiologic Studies of the Elderly.
A total of 7959 persons aged 68 years or older.
The incidence of deep venous thrombosis and pulmonary embolism was assessed by surveying hospital discharge diagnoses and deaths from 1985 through 1992. Those participants who estimated they used alcohol less than 1 time, on average, in the past month, less than 1 ounce per day, and 1 ounce or more per day were compared with those who reported no alcohol intake in the past year. Age, gender, race, body mass index, smoking, education, income, disability, cognitive function, arterial pressure, medication use, baseline chronic conditions, number of hospital admissions in past year, and occurrence of disease during follow-up were examined as possible confounders.
During 48,038 person-years of follow-up, 155 events were observed (35 deep venous thromboses and 123 pulmonary emboli). Compared with non-drinkers, after adjusting for potential confounding variables, the relative risks (95% confidence interval) for deep venous thrombosis and pulmonary embolism associated with increasing alcohol consumption levels were 0.7 (0.4-1.1), 0.6 (0.4-0.9), and 0.5 (0.2-1.1), respectively (P for trend = .004). The results were unchanged after stratifying on health status and disability.
Low to moderate alcohol consumption is associated with a decreased risk of deep venous thrombosis and pulmonary embolism in older persons.
评估低度至中度饮酒是否会降低深静脉血栓形成和肺栓塞的风险。
前瞻性队列研究。
老年流行病学研究既定人群的三个社区。
共有7959名68岁及以上的人。
通过调查1985年至1992年的医院出院诊断和死亡情况来评估深静脉血栓形成和肺栓塞的发生率。将那些估计自己在过去一个月中平均饮酒少于1次、每天少于1盎司以及每天1盎司或更多的参与者与那些报告过去一年不饮酒的参与者进行比较。将年龄、性别、种族、体重指数、吸烟、教育程度、收入、残疾、认知功能、动脉压、药物使用、基线慢性病、过去一年的住院次数以及随访期间的疾病发生情况作为可能的混杂因素进行检查。
在48038人年的随访期间，观察到155例事件（35例深静脉血栓形成和123例肺栓塞）。与不饮酒者相比，在调整潜在混杂变量后，与饮酒量增加相关的深静脉血栓形成和肺栓塞的相对风险（95%置信区间）分别为0.7（0.4 - 1.1）、0.6（0.4 - 0.9）和0.5（0.2 - 1.1）（趋势P值 = 0.004）。按健康状况和残疾分层后结果不变。
低度至中度饮酒与老年人深静脉血栓形成和肺栓塞风险降低有关。
