Tabone M, Galatola G, Secreto P, Marini C, Molinaro G, Aricò' S
Division of Gastroenterology, Ospedale Mauriziano Umberto I di Torino, Italy.
J Viral Hepat. 1994;1(2):155-7. doi: 10.1111/j.1365-2893.1994.tb00115.x.
We measured the optical densities (OD) of serum anti-hepatitis C virus IgM core antibodies in 40 HCV-positive patients (24 males and 16 females) with histologically proven chronic active hepatitis but without cirrhosis. All patients were treated with i.m. injections of 3 MU thrice weekly of interferon-alpha (IFN-alpha) for 6 months and followed-up monthly. Optical densities were evaluated in thawed sera before beginning treatment and 6 months after completion, and in fresh sera obtained at the end of an 8-12-month follow-up period. Patients were grouped into three categories according to the OD obtained: < 0.3 (negative test); 0.3-0.6 (intermediate positivity); > 0.6 (high positivity). According to the response to treatment during the follow-up period, patients were further divided into three classes: sustained responders; relapsers or partial responders; non-responders. In each patient, the OD values were similar in the three determinations before, after therapy and at the end of the follow-up period. All patients with an intermediate positive test for anti-HCV IgM core antibodies were relapsers or partial responders, and all patients with high OD values were non-responders. Conversely, 71% of the patients with a negative test were sustained responders. We conclude that this cheap and easily performed test may be useful in predicting the response to IFN therapy.
我们检测了40例经组织学证实为慢性活动性肝炎但无肝硬化的丙型肝炎病毒（HCV）阳性患者（24例男性和16例女性）血清抗丙型肝炎病毒IgM核心抗体的光密度（OD）。所有患者接受肌肉注射，每周三次，每次3 MU的α干扰素（IFN-α），共治疗6个月，并每月进行随访。在开始治疗前和解冻后的血清中以及在8 - 12个月随访期结束时采集的新鲜血清中评估光密度。根据获得的OD值将患者分为三类：<0.3（检测阴性）；0.3 - 0.6（中度阳性）；>0.6（高度阳性）。根据随访期间的治疗反应，患者进一步分为三类：持续应答者；复发者或部分应答者；无应答者。在每位患者中，治疗前、治疗后和随访期结束时的三次测定中OD值相似。所有抗HCV IgM核心抗体检测为中度阳性的患者均为复发者或部分应答者，所有OD值高的患者均为无应答者。相反，检测阴性的患者中有71%为持续应答者。我们得出结论，这项廉价且易于操作的检测可能有助于预测对IFN治疗的反应。
