Gürses N, Kalayci A G, Işlek I, Us D
Department of Paediatrics, Ondokuz Mayis University School of Medicine, Samsun, Turkey.
Ann Trop Paediatr. 1996 Jun;16(2):173-5. doi: 10.1080/02724936.1996.11747822.
Herpes simplex encephalitis is an important disease characterized by focal haemorrhagic necrosis of the temporal and frontal lobes of the brain. The mortality rate may be as high as 70% of untreated cases. Isolation of the virus from brain tissue is the most reliable means of diagnosis. Although some non-invasive diagnostic modalities have been investigated, none is as reliable as brain tissue sampling. Despite acceptance that acyclovir sodium is the most effective drug for treatment, there is not a consensus on the dosage and duration of the antiviral therapy because some patients fail to respond and sometimes there is recurrence following therapy. We report a case of encephalitis in a previously normal host who died after a 13-day course of acyclovir therapy with isolation of HSV-type 1 from the brain post mortem.
单纯疱疹性脑炎是一种重要疾病，其特征为脑颞叶和额叶的局灶性出血性坏死。未经治疗的病例死亡率可能高达70%。从脑组织中分离出病毒是最可靠的诊断方法。尽管已经对一些非侵入性诊断方法进行了研究，但没有一种方法像脑组织取样那样可靠。尽管人们公认阿昔洛韦钠是最有效的治疗药物，但对于抗病毒治疗的剂量和疗程尚无共识，因为一些患者没有反应，而且治疗后有时会复发。我们报告一例先前健康的宿主发生脑炎的病例，该患者在接受13天阿昔洛韦治疗后死亡，死后从脑部分离出1型单纯疱疹病毒。
