Cowin P, Burke B
Department of Cell Biology, New York University Medical Center, NY 10016, USA.
Curr Opin Cell Biol. 1996 Feb;8(1):56-65. doi: 10.1016/s0955-0674(96)80049-4.
Associations between the cytoskeleton and cellular membranes, both within the cell and at points of cell contact, play a central role in determining cell shape and tissue integrity. During the past few years, it has become clear that many of these cytoskeleton-membrane interactions go far beyond simple mechanical linkages. For example, proteins that act as linker molecules at the adherens junctions and desmosomes in the plasma membrane have newly recognized functions in signal transduction pathways. These functions have profound effects on cell behaviour during development. In addition, within the nucleus, the lamin branch of the intermediate filament protein family appears to have a key role in defining the protein composition of the inner nuclear membrane by means of extensive interactions with integral membrane proteins. The identities of these integral membrane proteins are only now coming to light.
细胞骨架与细胞膜之间的联系，无论是在细胞内部还是在细胞接触点，在决定细胞形状和组织完整性方面都起着核心作用。在过去几年中，已经清楚地认识到，许多这类细胞骨架-膜相互作用远远超出了简单的机械连接。例如，在质膜的黏附连接和桥粒处作为连接分子的蛋白质，在信号转导途径中具有新发现的功能。这些功能对发育过程中的细胞行为有深远影响。此外，在细胞核内，中间丝蛋白家族的核纤层分支似乎通过与整合膜蛋白的广泛相互作用，在确定内核膜的蛋白质组成方面起着关键作用。这些整合膜蛋白的身份直到现在才逐渐明晰。
