Porter M E
Department of Cell Biology and Neuroanatomy, University of Minnesota Medical School, Minneapolis 55455-0217, USA.
Curr Opin Cell Biol. 1996 Feb;8(1):10-7. doi: 10.1016/s0955-0674(96)80042-1.
Progress in the sequence determination of dynein subunits is providing new insights into the locations of functional domains in these microtubule motors. Combined structural and biochemical analyses of flagellar mutations are also yielding information on the three-dimensional organization of the dynein arms and on the different components that target dynein arm assembly. Physiological approaches are revealing multiple pathways that regulate dynein activity.
动力蛋白亚基序列测定方面的进展为深入了解这些微管马达中功能域的位置提供了新线索。对鞭毛突变进行的结构与生化联合分析，也在产出有关动力蛋白臂三维结构组织以及靶向动力蛋白臂组装的不同组件的信息。生理学方法正揭示出调控动力蛋白活性的多种途径。
