Axonemal dyneins: assembly, organization, and regulation.

Progress in the sequence determination of dynein subunits is providing new insights into the locations of functional domains in these microtubule motors. Combined structural and biochemical analyses of flagellar mutations are also yielding information on the three-dimensional organization of the dynein arms and on the different components that target dynein arm assembly. Physiological approaches are revealing multiple pathways that regulate dynein activity.