通过脂质第二信使进行信号转导。

Signal transduction through lipid second messengers.

作者信息

Spiegel S, Foster D, Kolesnick R

机构信息

Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USA.

出版信息

Curr Opin Cell Biol. 1996 Apr;8(2):159-67. doi: 10.1016/s0955-0674(96)80061-5.

DOI:10.1016/s0955-0674(96)80061-5

PMID:8791422

Abstract

This review emphasizes the generation of glycerolipid and sphingolipid second messengers, and their molecular targets. The role of the phosphatidylinositol transfer protein and phospholipase D in signal transmission, and the structures of the 1, 2-diacylglycerol and calcium-binding sites of protein kinase C are discussed. Further, ceramide signaling through protein kinases and the role of cross-talk in the signaling of apoptosis and inflammation are addressed.

摘要

本综述着重阐述了甘油脂和鞘脂类第二信使的生成及其分子靶点。讨论了磷脂酰肌醇转移蛋白和磷脂酶D在信号传导中的作用，以及蛋白激酶C的1,2 - 二酰甘油和钙结合位点的结构。此外，还探讨了通过蛋白激酶的神经酰胺信号传导以及细胞凋亡和炎症信号传导中信号串扰的作用。