Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX 77840, USA.
Viruses. 2021 May 25;13(6):974. doi: 10.3390/v13060974.
Marek's disease virus (MDV) is an oncogenic avian alphaherpesvirus whose genome consists of unique long (UL) and short (US) regions that are flanked by inverted repeat regions. More than 100 open reading frames (ORFs) have been annotated in the MDV genome, and are involved in various aspects of MDV biology and pathogenesis. Within UL and US regions of MDV, there are several unique ORFs, some of which have recently been shown to be important for MDV replication and pathogenesis. In this review, we will summarize the current knowledge on these ORFs and compare their location in different MDV strains.
马立克氏病病毒（MDV）是一种致瘤性禽α疱疹病毒，其基因组由独特的长（UL）和短（US）区组成，两侧为反向重复区。MDV 基因组中已注释了 100 多个开放阅读框（ORF），涉及 MDV 生物学和发病机制的各个方面。在 MDV 的 UL 和 US 区中，有几个独特的 ORF，其中一些最近被证明对 MDV 的复制和发病机制很重要。在这篇综述中，我们将总结这些 ORF 的现有知识，并比较它们在不同 MDV 株中的位置。
