Ehlers M D, Mammen A L, Lau L F, Huganir R L
Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University, 725 N Wolfe Street, 900 Preclinical Teaching Building, Baltimore, MD 21205-2185, USA.
Curr Opin Cell Biol. 1996 Aug;8(4):484-9. doi: 10.1016/s0955-0674(96)80024-x.
The proper targeting and clustering of neurotransmitter receptors at appropriate postsynaptic sites are principal requirements for the formation of functional synapses. Recently, new studies have begun to elucidate the mechanisms underlying the targeting and clustering of glutamate receptors at excitatory synapses in the brain. Members of the SAP90/PSD-95 family of proteins have emerged as potential regulators of glutamate-receptor membrane distribution. Further, targeting motifs within glutamate receptor subunits have been identified. These findings provide important clues in the effort to understand the molecular features of synaptic organization.
神经递质受体在适当的突触后位点进行正确的靶向定位和聚集是形成功能性突触的主要要求。最近，新的研究已开始阐明大脑中兴奋性突触处谷氨酸受体靶向定位和聚集的潜在机制。SAP90/PSD - 95蛋白家族成员已成为谷氨酸受体膜分布的潜在调节因子。此外，已确定了谷氨酸受体亚基内的靶向基序。这些发现为理解突触组织的分子特征提供了重要线索。
