Guo S, Kemphues K J
Section of Genetics and Development, 101 Biotechnology Building, Cornell University, Ithaca, New York 14853, USA.
Curr Opin Genet Dev. 1996 Aug;6(4):408-15. doi: 10.1016/s0959-437x(96)80061-x.
Asymmetric cleavage plays an important role in Caenorhabditis elegans embryogenesis. In addition to generating cellular diversity, several early asymmetric cleavages contribute to the spatial organization of the embryo. Genetic and molecular analyses of several genes, including six par genes and the mex-1 and mes-1 genes, together with experimental embryological studies, have provided insights into mechanisms controlling polarity and spindle orientations during these cleavages. In particular, these studies focus attention on microfilament-based motility and changing protein distributions at the cell cortex.
不对称分裂在秀丽隐杆线虫胚胎发生过程中起着重要作用。除了产生细胞多样性外，一些早期的不对称分裂还对胚胎的空间组织有贡献。对包括六个par基因以及mex-1和mes-1基因在内的多个基因进行的遗传和分子分析，再加上实验胚胎学研究，为了解这些分裂过程中控制极性和纺锤体取向的机制提供了线索。特别地，这些研究将注意力集中在基于微丝的运动以及细胞皮层处不断变化的蛋白质分布上。
