Rusch J, Levine M
Department of Biology, Center for Molecular Genetics, 2100 Pacific Hall,9500 Gilman Drive, University of California at San Diego, La Jolla, 92093-0347, USA.
Curr Opin Genet Dev. 1996 Aug;6(4):416-23. doi: 10.1016/s0959-437x(96)80062-1.
Dorsoventral patterning in Drosophila is initiated by the maternal regulatory factor dorsal (dl), which is a member of the Rel family of transcription factors. dl functions as a transcriptional activator and repressor to establish different territories of gene expression in the precellular embryo. Differential regulation of dl target genes may be essential for subdividing each tissue territory (the presumptive mesoderm, neuroectoderm, and dorsal ectoderm) into multiple cell types in older embryos. Different patterns of snail (sna) and decapentaplegic (dpp) expression help define the limits of inductive interactions between the mesoderm and dorsal ectoderm after gastrulation. Similarly, the differential regulation of short gastrulation (sog) and dpp may be decisive in the initial subdivision of the dorsal ectoderm, whereas different limits of gene expression within the neuroectoderm might provide the basis for the subsequent subdivision of this tissue into ventral and lateral regions.
果蝇的背腹模式形成由母体调控因子背蛋白（dorsal，dl）启动，它是转录因子Rel家族的成员。dl作为转录激活因子和阻遏因子，在细胞前胚胎中建立不同的基因表达区域。dl靶基因的差异调控对于在较老胚胎中将每个组织区域（推定的中胚层、神经外胚层和背外胚层）细分为多种细胞类型可能至关重要。蜗牛基因（snail，sna）和骨形态发生蛋白基因（decapentaplegic，dpp）的不同表达模式有助于确定原肠胚形成后中胚层和背外胚层之间诱导相互作用的界限。同样，短原肠胚形成基因（short gastrulation，sog）和dpp的差异调控可能在背外胚层的初始细分中起决定性作用，而神经外胚层内不同的基因表达界限可能为该组织随后细分为腹侧和外侧区域提供基础。
