红霉素对人体胆道运动的影响。

Effect of erythromycin on human biliary motility.

作者信息

Wehrmann T, Pfeltzer C, Caspary W F

机构信息

Department of Internal Medicine II, J. W. Goethe University Hospital, Frankfurt am Main, Germany.

出版信息

Aliment Pharmacol Ther. 1996 Jun;10(3):421-6. doi: 10.1111/j.0953-0673.1996.00421.x.

DOI:10.1111/j.0953-0673.1996.00421.x

PMID:8791972

Abstract

BACKGROUND

To investigate the effects of intravenous erythromycin on human gall-bladder and sphincter of Oddi motor function.

METHODS

Twelve consecutive patients with suspected sphincter of Oddi dysfunction were studied. Gall-bladder function was assessed by ultrasonography, and sphincter of Oddi motility was evaluated by means of endoscopic manometry.

RESULTS

All patients were found to have normal gall-bladder function. The percentage of maximal gall-bladder emptying following a standardized, liquid test meal was significantly increased by erythromycin, whereas the postprandial residual gall-bladder volume was significantly decreased after erythromycin (P < 0.01). Endoscopic manometry revealed the presence of sphincter of Oddi dysfunction in two of the 12 patients. Erythromycin significantly decreased the basal sphincter of Oddi pressure and slowed the sphincter of Oddi phasic contraction frequency in all patients (P < 0.01). However, the mean duration of the sphincter phasic contractions (P < 0.05) and their amplitude (P = 0.05) were increased by the compound.

CONCLUSIONS

Erythromycin stimulates gall-bladder motility but induces varying effects on human sphincter of Oddi motility.

摘要

背景

研究静脉注射红霉素对人体胆囊及Oddi括约肌运动功能的影响。

方法

对连续12例疑似Oddi括约肌功能障碍的患者进行研究。通过超声检查评估胆囊功能，借助内镜测压法评估Oddi括约肌运动。

结果

所有患者胆囊功能均正常。红霉素使标准化液体试验餐后胆囊最大排空百分比显著增加，而餐后残余胆囊体积在使用红霉素后显著减少（P < 0.01）。内镜测压显示12例患者中有2例存在Oddi括约肌功能障碍。红霉素显著降低所有患者的Oddi括约肌基础压力，并减缓Oddi括约肌的相性收缩频率（P < 0.01）。然而，该化合物使括约肌相性收缩的平均持续时间增加（P < 0.05），收缩幅度也增加（P = 0.05）。